Next, the researchers introduced into the bladders of the mice either Lactobacillus crispatus, a normal vaginal bacterium G.
coli can persist in the bladder at levels undetectable in the urine. However, previous studies had shown that a small population of E. coli, initiating UTIs, and then let them recover. The condition is associated with UTIs.Īs part of the study, the researchers infected the bladders of female mice with E. The reasons why UTIs recur is not fully understood, but the researchers, including obstetrics and gynecology instructor Nicole Gilbert, PhD, and graduate student Valerie O’Brien, saw a clue in bacterial vaginosis, which is caused by an overgrowth of harmful bacteria, resulting in vaginal odor and discharge. But this is the first study to identify a plausible trigger. coli in the bladder and later be reactivated to cause infection. coli bacteria can create dormant hiding places for E. Previous studies already had established that E. Small molecules block bacteria from attaching to, infecting bladder Related: Novel approach shows promise against UTIs coli from a previous UTI to start multiplying, leading to another bout of disease,” said the study’s senior author, Amanda Lewis, PhD, an assistant professor of molecular microbiology and of obstetrics and gynecology at Washington University. “We found that a particular vaginal bacterium, Gardnerella vaginalis, did not cause infection during exposure to the urinary tract, but it damaged the cells on the surface of the bladder and caused E. vaginalis also may be a contributor to more serious – and potentially deadly – kidney infections, the study suggests.
coli already hiding in the bladder to cause another UTI. But the new research suggests another way for a subsequent UTI to develop: The vaginal bacterium Gardnerella vaginalis triggers E. coli is reintroduced into the urinary tract. Conventional thinking holds that recurrence occurs when E. In young, sexually active women, about 80 percent of UTIs are caused by E.
UTIs are treated with antibiotics, but each time a UTI comes back makes it even more likely the infection will recur yet again. The infections can occur anywhere along the urinary tract but commonly develop in the bladder. UTIs most often occur when bacteria that live inside the bowel make their way into the urinary tract. The research, in mice, is published March 30 in PLOS Pathogens. Louis has uncovered a trigger of recurrent UTI infections: a type of vaginal bacteria that moves into the urinary tract. vaginalis is dying and detaching from its neighboring cells (teal), revealing immature cells below (purple).Ībout half of all women will experience urinary tract infections in their lifetimes, and despite treatment, about a quarter will develop recurrent infections within six months of initial infection.Ī new study at Washington University School of Medicine in St. In the image, a bladder cell (blue) that has been exposed to G. GilbertĪ kind of bacteria found in the vagina may trigger recurrent UTIs, according to a new study at Washington University School of Medicine in St. News Release Vaginal bacteria can trigger recurrent UTIs, study showsįindings help explain UTI link to sexual activityīy Tamara Bhandari
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